Sunday, December 25, 2016

How employable is Brock Turner?


At first, I was aghast to come across a question that seems insensitive and preposterous. Evidence unanimously proves a privileged young white man, Brock Turner, committed a heinous crime, sexually assaulting an unconscious woman. Such odious behavior has now been amply compounded by consistent absence of remorse and flagrantly disingenuous attempts to deflect responsibility. Yet, there is apparent solicitous concern about how this affects such a sorry soul's future career prospects? If that isn't a blatant example of misplaced sympathy, I don't know what is. Of course, Quora offers a tool to deal with 'bad' questions, just downvote them. However, sometimes bad questions also provide teachable moments. I think this one certainly does.

One teachable moment comes from probing why such solicitous concern for Brock Turner's but not for Cory Batey's future career options. Cory who you ask?


Another teachable moment comes from asking why such different sentences for two rather similar crimes. If anything, for such heinous crimes both defendants should have received similar, harsh sentences. So why such difference in sentencing?

Black (Batey) versus white (Turner) defendant, is one possibility (see below from 1).


Black (Judge Monte Wilkins; Tennessee Administrative Office of the Courts) versus white (Judge Aaron Persky; Aaron Persky) judge, is another possibility (see below from 1).


Obviously some justice enforcers are color-blind as indeed they should be while justice itself is apparently blind...to racial disparity that is. A 2013 report to the UN Human Rights Committee shows blacks in the US are routinely disproportionately arrested, convicted and sentenced for comparable crimes (2). Are such disparities surprising in a culture where solicitous concern expressed for a white but not black perpetrator of rather similar, heinous crimes is apparently normal?
Teachable moments do have a problem in that there's no guarantee they're equally learnable moments. The latter depends on the students, questioners and/or readers in this case. After all, one can take a horse to water but can't make it drink.

Bibliography
1. King: Brock Turner and Cory Batey, two college athletes who raped unconscious women, show how race and privilege affect sentences. Shaun King, New York Daily News, Tuesday, June 7, 2016. KING: Brock Turner, Cory Batey show how race affects sentencing
2. Report of The Sentencing Project to the United Nations Human Rights Committee. Regarding Racial Disparities in the United States Criminal Justice System. August 2013. http://sentencingproject.org/wp-...


https://www.quora.com/How-employable-is-Brock-Turner/answer/Tirumalai-Kamala


Sunday, December 18, 2016

What is the reputation of John Carreyrou, the investigative reporter who wrote a critical piece about Theranos, like?


John Carreyrou 's Wikipedia page does a good job of summarizing his rather stellar journalism career thus far. Focusing on American journalism awards, during his time at the The Wall Street Journal (WSJ), he's won two Pulitzer Prizes and one Polk Award,
  • One, a shared Pulitzer prize for Explanatory Reporting in 2002 for coverage of some corporate scandals (1, 2),
  • Two, a shared Pulitzer prize for Investigative Reporting in 2015 for coverage of widespread US medical doctors' bilking of Medicare (see photo below from 3; 4, 5, 6).
  • Three, in 2016, the George Polk Awards bestowed Carreyrou an individual Financial Reporting award for his coverage of Theranos. The Polk citation states (7, 8),
'The award for Financial Reporting will go to John Carreyrou of The Wall Street Journal whose investigation of Theranos, Inc. raised serious doubts about claims by the firm and its celebrated 31-year-old founder, Elizabeth Holmes, that its new procedure for drawing and testing blood was a transformational medical breakthrough in wide use at the firm’s labs. Carreyrou’s well-researched stories, reported in the face of threats of lawsuits and efforts to pressure some sources to back off of their accounts, led to a reevaluation of Theranos’ prospects among investors and have been followed by regulatory actions against the company and widespread discussion that publications and institutions from Fortune and The New Yorker to Harvard and the White House may have been too quick to hail Holmes, a Stanford dropout whose personal wealth at the height of her startup’s rise was an estimated $4.5 billion, as a success story in the tradition of Steve Jobs, Bill Gates and Mark Zuckerberg'
Let's also be clear. John Carreyrou didn't write 'a' but rather all the relevant critical WSJ pieces about Theranos either alone (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20) or with Rolfe Winkler (21) or with Christopher Weaver and/or Michael Siconolfi (22, 23, 24, 25, 26, 27, 28).

In contrast to the 'access-driven cheerleading' (29) currently consuming technology journalism, Carreyrou pursued the Theranos case with dogged determination. Key aspect of the Carreyrou-WSJ Theranos exposes includes the numerous former and present as-yet anonymous employees who apparently proffered sensitive information at considerable peril to themselves. Clearly Carreyrou is skilled in seeking out and cultivating confidential contacts crucial to his story. Kudos to Carreyrou-WSJ for continuing to maintain their contacts’ confidentiality and for not caving to the alleged intimidating legal tactics used by Theranos (see excerpt below from 30).
'After two months of being stonewalled by the Theranos P.R. team, Carreyrou told me an entourage of lawyers arrived at the Journal ’s Midtown Manhattan offices at one P.M. on June 23. The pack confidently sauntered past editors and reporters in the fifth-floor newsroom and was led by David Boies, the superstar lawyer who has taken on Bill Gates, the U.S. government, and represented Al Gore in the 2000 Florida recount case. Four other attorneys and a Theranos representative accompanied him. Before anything was said, the lawyers placed two audio recorders at either end of the long oval wood table, and recalcitrantly sat across from Carreyrou, his editor, and a Journal lawyer. Then they hit record.
Almost immediately, one person present told me, Boies and his team threatened legal action against the paper, accusing it of being in possession of “proprietary information” and “trade secrets.” The Theranos legal team then did their best to discredit dozens of independent sources whom Carreyrou had interviewed. The legal team roared, they showed teeth, they tried to intimidate. After a very tense five hours, the person told me that Boies and his platoon exited the newsroom, leaving behind the very serious specter of a lawsuit. (A spokesperson for both Boies and Theranos declined to comment. But one person close to the company said that Boies had been dispatched because Theranos executives had learned that the Journal possessed sensitive internal documents.)
For four months after that meeting, Carreyrou continued to try to secure an interview with Holmes, and for four months he was continuously threatened. Finally, in October, the Journal published its now-famous article suggesting that the Theranos narrative was all wrong—that the company’s technology was faulty, that it relied on other companies’ machinery to run many of its tests, and that some of those tests yielded inaccurate results. In fact, as Carreyrou reported, the company was hawking a tale that was too good to be true.'
Bibliography
  1. The 2003 Pulitzer Prize in Explanatory Reporting. Staff of The Wall Street Journal
2. The Wall Street Journal, John Carreyrou and Martin Peers, October 31, 2002. How Messier Kept Cash Crisis At Vivendi Hidden for Months
3. The 2015 Pulitzer Prize in Investigative Reporting. The Wall Street Journal Staff
4. Medicare Unmasked. The Wall Street Journal forced the government to publicly release important Medicare data that had been kept secret for decades. http://www.pulitzer.org/files/20...
5. Medicare Unmasked. Sprawling Medicare Struggles To Fight Fraud. http://www.pulitzer.org/files/20...
6. Medicare Unmasked. Doctor “Self-Referral” Thrives on Legal Loophole. http://www.pulitzer.org/files/20...
7. 67th Annual George Polk Awards in Journalism. LIU 2015 Winners
9. The Wall Street Journal, John Carreyrou, October 16, 2015. Hot Startup Theranos Has Struggled With Its Blood-Test Technology
10. The Wall Street Journal, John Carreyrou, October 16, 2015. Hot Startup Theranos Dials Back Lab Tests at FDA’s Behest
11. The Wall Street Journal, John Carreyrou, October 21, 2015. Theranos CEO: Company Is in a ‘Pause Period’;
12. The Wall Street Journal, John Carreyrou, November 6, 2015. Theranos Searches for Director to Oversee Laboratory
13. The Wall Street Journal, John Carreyrou, November 10, 2015. Safeway, Theranos Split After $350 Million Deal Fizzles
14. The Wall Street Journal, John Carreyrou, December 20, 2015. U.S. Probes Theranos Complaints
15. The Wall Street Journal, John Carreyrou, December 27, 2015. At Theranos, Many Strategies and Snags
16. The Wall Street Journal, John Carreyrou, January 27, 2016. Theranos Lab Practices Pose Risk to Patient Health, Regulators Say
17. The Wall Street Journal, John Carreyrou, February 10, 2016. Walgreens Threatens to End Theranos Agreement
18. The Wall Street Journal, John Carreyrou, March 28, 2016. Theranos Results Could Throw Off Medical Decisions, Study Finds
19. The Wall Street Journal, John Carreyrou, May 12, 2016. Theranos Executive Sunny Balwani to Depart Amid Regulatory Probes
20. The Wall Street Journal, John Carreyrou, May 18, 2016. Theranos Voids Two Years of Edison Blood-Test Results
21. The Wall Street Journal, Rolfe Winkler and John Carreyrou, October 28, 2015. Theranos Authorizes New Shares That Could Raise Valuation
22. The Wall Street Journal, John Carreyrou, Christopher Weaver and Michael Siconolfi, January 24, 2016. Deficiencies Found at Theranos Lab
23. The Wall Street Journal, Christopher Weaver, Michael Siconolfi and John Carreyrou, February 10, 2016. Walgreens Threatens to End Theranos Agreement
24. The Wall Street Journal, John Carreyrou and Christopher Weaver, March 8, 2016. Theranos Ran Tests Despite Quality Problems
25. The Wall Street Journal, John Carreyrou and Christopher Weaver, March 31, 2016. Theranos Devices Often Failed Accuracy Requirements
26. The Wall Street Journal, John Carreyrou and Christopher Weaver, April 13, 2016. Regulators Propose Banning Theranos Founder Elizabeth Holmes for at Least Two Years
27. The Wall Street Journal, Christopher Weaver, John Carreyrou and Michael Siconolfi, April 18, 2016. Theranos Is Subject of Criminal Probe by U.S.
28. The Wall Street Journal, John Carreyrou, Christopher Weaver and Michael Siconolfi, May 25, 2016. Craving Growth, Walgreens Dismissed Its Doubts About Theranos
29. Gawker, J.K. Trotter, May 26, 2016. This Is Why Billionaire Peter Thiel Wants to End Gawker
30. The Vanity Fair, Nick Bilton, May 2, 2016. The Secret Culprit in the Theranos Mess


https://www.quora.com/What-is-the-reputation-of-John-Carreyrou-the-investigative-reporter-who-wrote-a-critical-piece-about-Theranos-like/answer/Tirumalai-Kamala


Sunday, December 11, 2016

Why is home birth in America so dangerous when compared to other comparable countries?


Refers to article: http://www.nytimes.com/2016/05/01/opinion/sunday/why-is-american-home-birth-so-dangerous.html?ref=opinion
 
Firm conclusions aren't possible from the New York Times article referred in the question since it examines a minuscule piece of the pie. However, analyzing in conjunction with other relevant data such as excess medicalization propensity of US births, total US maternal mortality and overall medical error rates suggests US home births are unlikely to get a fair chance because they simply aren't integrated with OB/GYN practices and hospitals, making it practically impossible to optimally co-ordinate care, if and when an in-labor transfer is necessary from home/birthing center to hospital. However, doing so would not only greatly reduce short- and long-term costs and rates of medically unnecessary C-sections but also improve both short- and long-term outcomes for maternal and fetal health.
Unfortunately this is easier said than done since, perhaps more than in other countries, US medicine in general and US births in particular exist at the uneasy intersection of medicine, politics and law. Unfortunately, this toxic mix pollutes every aspect of the birth process, from greater propensity for unnecessary medicalization (off-label use of Misoprostol for cervical ripening and excessive C-section rates being examples) to questionable data, all predictable responses of a system driven more by need for institutional control and liability avoidance rather than scientific allegiance to evidence-based medicine.

US Births Increasingly Medicalized, Having Among The Highest Rates Of C-Sections
The late American perinatologist and perinatal epidemiologist Marsden Wagner, divided current human birth processes into 3 broad categories (1).
  • Highly medicalized, 'high tech', doctor-centric, midwife-marginalized. Examples found in Belgium, urban Brazil, Czech Republic, France, Ireland, Russia, USA.
  • Humanized, more autonomous, strongly midwife-centric with much lower intervention rates. Examples found in the Netherlands, New Zealand and Scandinavia.
  • Mixture of both approaches. Examples found in Australia, Britain, Canada, Germany, Japan.
Problem with the first option that dominates in the US is that over the course of the 20th century and beyond, it helped inculcate an institutional and cultural memory of medicalized birth at the expense of humanized birth. To quote from the 1985 report Wagner helped publish as the Director of the WHO's Women's and Children's Health (1) (emphasis mine),
'By medicalizing birth, i.e. separating a woman from her own environment and surrounding her with strange people using strange machines to do strange things to her in an effort to assist her, the woman’s state of mind and body is so altered that her way of carrying through this intimate act must also be altered and the state of the baby born must equally be altered. The result it that it is no longer possible to know what births would have been like before these manipulations. Most health care providers no longer know what “non-medicalized” birth is. The entire modern obstetric and neonatological literature is essentially based on observations of “medicalized” birth.'
For example, according to the US National Center for Health Statistics, 1 in 3 babies is delivered by C-section in the US (2). US C-section rates are much higher compared to other OECD countries (see figures below from 2, 3, 4, 5). This even though the WHO has recommended for more than 30 years that C-sections shouldn't be >10 to 15% of total births (5, 6).


US C-sections rates are one of the clearest pieces of evidence for excess medicalization of US births. C-section risks aren't limited to mothers' immediate higher risks of post-surgical complications either. As we learn more about the importance of immediate post-birth microbial colonization, epidemiology is steadily building a hefty database of children's long-term adverse outcomes of C-sections, namely life-long increased risks of allergies and autoimmunities (7, 8).
Since home births are a minuscule proportion of total births, accounting for a mere 1.47% of total births as recently as 2014 (see table below from 9), obviously US C-sections can't simply be attributed to home birth complications that necessitate in-labor transfers to hospitals for emergency C-sections. Rather, they're a logical expansion of excessive medicalization of US births in general.


No Firm Conclusions Possible When Available Data Are Suspect
Inextricably linked to the larger issue of births and maternal health in general, not just home births but also maternal mortality rates in the US buck global trends. A 2014 assessment of global maternal mortality rates shockingly revealed that the US is the only developed country where the maternal mortality rate seems to be increasing even as it's decreasing across the globe (10). According to this study, US maternal mortality rate per 100000 live births were 12.4 in 1990, 17.6 in 2003 and 18.5 in 2013, meaning they increased 2.7% from 1990 to 2003, increased 0.5% from 2003 to 2013, and increased 1.7% from 1990 to 2013 (see figures below from 11). Since home births are a minuscule proportion of total US births, this implies maternal mortality rate is increasing in US hospital births.


Increasing US maternal mortality fits into the larger issue of medical errors. A 2016 study extrapolated data to suggest medical errors have now become the 3rd leading cause of deaths in the US (12). While statistical over-reach is a major weakness of this study, it's long been an open secret that frank admission of error is practically impossible in medical culture (13). Since deaths incurred during or through hospital births (complications following C-sections for example) fall under the medical error rubric, data related to births, be they home or hospital, especially data on adverse outcomes, can only be taken with a generous pinch of salt.
Doubts about accuracy of maternal death data become an even more pressing issue given that there are no US federal requirements to report maternal deaths and US authorities themselves concede they may be twice as high as reported (14). According to Amnesty International (15) (emphasis mine),
'reporting of pregnancy -related deaths as a distinct category is mandatory in only six states – Florida, Illinois, Massachusetts, New York, Pennsylvania and Washington. Despite voluntary efforts in some other states, systematic undercounting of pregnancy -related deaths persists'
Bottomline, data on US deaths due to either home or hospital births are far from reliable.

Amy Tuteur, Author Of This New York Times Article, Has A Patently Clear Conflict Of Interest
As author of the blog, The Skeptical OB, Amy Tuteur, the author of this New York Times piece, has a patently clear conflict of interest regarding home births. She herself revealed this bias in her incorrect criticism (16) of a large, thorough 2013 British Medical Journal study comparing maternal mortality between home and hospital births in the Netherlands (17). After misunderstanding this Netherlands data and incorrectly critiquing it, a volte-face to say the least when she writes in this New York Times piece 'there are places in the world where home birth is relatively safe, like the Netherlands, where it is popular at 16 percent of births' (18). So, per this author, are home births in the Netherlands safe or not? When an author's opinion varies based on the context, better not to take such opinions at face value.

Birth Is A Normal Physiologic Process. Medicalizing It Changes It From A Sanctuary To Surveillance, Often To Mother And Child's Detriment
As we understand better the short- and long-term harms of birth medicalization, we see its costs are paid not just by mothers and children but by all of society, economic, physiological and psychological costs from avoidable chronic health conditions.
A highly medicalized, overweeningly C-section-favoring approach to birth prevails in the US. It represents a financial medico-legal culture highly resistant to the notion of home births. Primed to regard midwifery as a potentially harmful interloper, such a culture easily gives it short shrift, depriving it the integration and co-ordination necessary to thrive and succeed. This reveals a schism in the US birth process, a schism between need for sanctuary during birth to ensure physiological processes prevail and need for surveillance to ensure technology provides state-of-the-art safe care (19).
Examining and importing best practices and structures from countries like Netherlands, adept at straddling the divide between home births and best of medical care, is an obvious approach. However, such measures require humility and an open mind. Is US medico-legal culture up to that challenge? That's the crucial question.

Bibliography
1. Wagner, Marsden. "Fish can't see water: the need to humanize birth." International Journal of Gynecology & Obstetrics 75 (2001): S25-S37. http://www.midwiferyservices.org...
2. Menacker, Fay, and Brady E. Hamilton. Recent trends in cesarean delivery in the United States. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, 2010. http://www.gapha.org/wp-content/...
3. Health at a Glance 2011. OECD Indicators.
5. World Health Organization. "WHO statement on caesarean section rates." (2015). http://apps.who.int/iris/bitstre...
6. Moore, Ben. "Appropriate technology for birth." The Lancet 326.8458 (1985): 787).
9. Grunebaum, Amos, and Frank A. Chervenak. "Out-of-hospital births in the United States 2009–2014." Journal of perinatal medicine (2016). http://www.degruyter.com/dg/view...
10. Kassebaum, Nicholas J., et al. "Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013." The Lancet 384.9947 (2014): 980-1004. http://www.ncbi.nlm.nih.gov/pmc/...
11. The US Is The Only Developed Nation With A Rising Maternal Mortality Rate. Anna Almendrala, The Huffington Post, May 19, 2014. This Is The Deadliest Industrialized Country For Pregnant Moms
12. Makary, Martin A., and Michael Daniel. "Medical error—the third leading cause of death in the US." BMJ 353 (2016): i2139. http://www.bmj.com/content/bmj/3...
14. Berg, Cynthia, et al. "Strategies to reduce pregnancy-related deaths: from identification and review to action." (2001)., Centers for Disease Control and Prevention, 2001. http://stacks.cdc.gov/view/cdc/6...
15. Delivery, Deadly. "The Maternal Health Care Crisis in the USA." London: Amnesty International (2010). http://www.amnestyusa.org/sites/...
17. de Jonge, Ank, et al. "Severe adverse maternal outcomes among low risk women with planned home versus hospital births in the Netherlands: nationwide cohort study." BMJ 346 (2013): f3263. http://www.bmj.com/content/bmj/3...
18. Why Is American Home Birth So Dangerous? The New York Times, Amy Tuteur, April 30, 2016.
19. Stenglin, Maree, and Maralyn Foureur. "Designing out the Fear Cascade to increase the likelihood of normal birth." Midwifery 29.8 (2013): 819-825.


https://www.quora.com/Why-is-home-birth-in-America-so-dangerous-when-compared-to-other-comparable-countries/answer/Tirumalai-Kamala


Sunday, December 4, 2016

What do scientists think about Sci-Hub?


 Refers to articles: http://www.sciencemag.org/news/2016/04/whos-downloading-pirated-papers-everyone, http://www.sciencemag.org/news/2016/04/alexandra-elbakyan-founded-sci-hub-thwart-journal-paywalls

Presumably most respondents who took Science magazine's recent survey were scientists (1). Results suggest they whole-heartedly endorse Sci-Hub (see figures below from 1).


  • 88% say it isn't wrong to download pirated papers.
  • For >50%, it's the only way to access scientific papers.
  • >60% think Sci-Hub will disrupt traditional scientific publishing.
Sci-Hub and Alexandra Elbakyan have accomplished two important breakthroughs
  • Provided pirated access to paywalled scientific journals and in doing so, revealed the previously unimagined extent to which scientists the world over lacked access to scientific papers, often to even their own published work.
  • Brought Scientific Publishing to mainstream awareness. While the odium and coercion inherent to its structure are well-known to scientists themselves or should be at the very least, Sci-Hub and Elbakyan have helped cast a more prominent spotlight on it so it's under broader scrutiny, helping fuel its long overdue Napster moment.
What Sci-Hub and Elbakyan have done and why can only be fully appreciated by understanding what Scientific Publishing's odium and coercion consist of, and why in hindsight it seems inevitable something like Sci-Hub would come up sooner or later.

Scientific Publishing In A Nutshell
  • Most basic science research is taxpayer-funded.
  • Scientific credibility and career advancement, especially in academia, depend on peer-reviewed scientific publication of such research.
  • Enter Scientific Publishing.
    • Dominated by for-profit publishing houses like Elsevier, Springer-Nature, Wiley to name a few, whose platforms publish among the most prestigious scientific journals in the various scientific specialities.
    • Publishing in such journals is considered necessary for scientists to accrue credibility and advancement.
    • In a throwback to post-Renaissance Independent scientist, scientists, as editorial board members and even just peers, perform peer-review of each other's manuscripts pro-bono (free), meaning free of cost to Scientific Publishers.
    • Burden of Scientific Publishers is mainly limited to page layouts, editing and publishing, now mainly online.
      • Since the internet exploded in the mid-1990s, most Scientific Publishers have migrated online and their costs have dramatically reduced since electronic publishing costs a fraction of print.
      • Scientific Publishers manage to cut administrative costs even more to the bone by out-sourcing editing processes to back offices in developing countries.
    • Scientific Publishers typically own the copyright to papers scientists publish on their journals. Why? Answer's lost to the mists of time.
    • For-profit Scientific Journals are typically Paywalled: Scientific Publishers charge an arm and a leg for accessing just one paper on their web-sites. Such paywalls can range from US $6 to >$50 for just one paper, even for papers published decades earlier, and even for scientists who've published in those same journals and/or have peer-reviewed pro bono on their behalf.
    • Annual subscriptions to the thousands of journals published by these Scientific Publishers is an onerous financial burden even for the best-endowed universities in the world like Harvard (2).
In other words, established, for-profit Scientific Publishers are middlemen making money hand over fist for work product that's largely taxpayer-funded, then deemed worthy of publication free of cost by scientific peers, who then have to pay through their noses to access their own published work, which by the way they don't even own the copyright to. For people considered really smart by the rest of society, how could scientists have allowed themselves to be bamboozled to such an extent? A question for the ages, that.

The explosion of the internet brought the fruits of scientists' labor that much closer to their brethren the world over but in this case, the Digital divide's exacerbated by the outrageously priced paywalls. Science is a rather unique enterprise in that it's essentially cooperative and collaborative, and advances by Standing on the shoulders of giants, as the saying goes. In practical terms, this means accessing and reading hundreds to thousands of peer-reviewed scientific papers relevant to one's own field of study, both in helping formulate one's own scientific work as well as citing these other studies to help rationalize one's results and help justify one's interpretation. If Harvard finds it hard to subscribe to all scientific journals its students need, no way a Kazakhstan scientist like Elbakyan could access and download all the papers necessary for their research. Thus, sheer frustration with an untenable status quo likely drove the creation of Elbakyan's mirror site, Sci-Hub.

Open-access Scientific Journals: Their Advantages And Pitfalls
Since the 2000s, Open access journals have appeared as an economically less onerous alternative to the robber baron for-profit Scientific Publishers. However, open access journals have at least three obstacles they haven't yet managed to successfully overcome.
  • One, path to successful grants and promotions is greased by prestigious peer-reviewed publications. This is still largely the purview of for-profit journals who accrued such prestige over decades, some, even centuries. Big names and big name wannabees in various scientific sub-fields prop up this status quo by continuing to publish their 'best' work in these journals rather than gravitating to their newer, less notable, open-access counterparts. Though big names like Fields Medal winning mathematician Timothy Gowers (3), and Nobel Prize-winner Randy Schekman (4) have openly proclaimed their rejection of these so-called 'luxury' journals, the trickle hasn't yet become a flood, and rank and file scientists continue to offer their 'best' work to long-established, for-profit, paywalled prestige journals.
  • Two, current open-access largely subsidizes free access through prohibitive front-end costs to authors who publish in them. In the post-Great Recession world, when even government-funded labs are forced to cut costs to the bone, paying on average ~US $2000 to get a paper published in PLOS or BioMed Central is an onerous financial burden. Plos and BioMedCentral are examples of open access publishers who've managed to accrue prestige sufficient to be competitive against their older for-profit counterparts.
  • Three, sensing opportunity, open-access has become a lure attracting a host of rapacious publishers looking to make a killing. They offer junior scientists the opportunity to both publish and peer-review on their journals, and use this imprimatur to attract their peers but ultimately their editorial processes are far less stringent to the established norms. Papers published in these ever-mushrooming journals muddy the scientific waters, making it more difficult for the rank and file traditional speciality science journals to distinguish themselves from their newer, predatory counterparts. This problem has assumed such epidemic proportions that Jeffrey Beall, librarian at Auraria Library, University of Colorado, Denver, Colorado, annually publishes his list of predatory, open-access publishers (5) to help scientists sift gold from dross in Scientific Publishing.
Science publishing, especially in biomedical research, is thus passing through one of its most momentous transitions. Heavyweights in the public health arena like the Bill & Melinda Gates Foundation have instituted guidelines mandating publications ensuing from their grants be published in open-access journals starting in January 2017 (6). The Gates Foundation will pay the author fees charged by such open-access journals. The onus is now on governments, other science funders, universities and research institutes to develop approaches that ensure taxpayer-funded research becomes open-access for all from the moment they're published, regardless of the journal it's published in. After all, as things stand, imprimatur of peer-review remains the gold standard for grants and career advancement in science, at least in biomedical research. At this moment, it’s unclear how experiments like bioRxiv, pre-publication repository of raw biology data, will influence scientists’ careers.

Bibliography
1. In survey, most give thumbs-up to pirated papers. Science, John Travis, May 6, 2016.
2. Harvard University says it can't afford journal publishers' prices. The Guardian, Ian Sample, April 24, 2012.
3. Elsevier — my part in its downfall. Tim Gowers, Jan 21, 2012.
6. Gates Foundation to require immediate free access for journal articles. Science, Jocelyn Kaiser, November 21, 2014.


https://www.quora.com/What-do-scientists-think-about-Sci-Hub/answer/Tirumalai-Kamala


Sunday, November 27, 2016

Why do people believe that bottled water is better than tap water?


People may or may not have started out believing bottled water is better than tap water. However for >20 years now in the US, they've certainly been marketed to that way and consumption patterns suggest it worked.

In 1975, Americans hardly drank bottled water, just one gallon of bottled water per person per year on average. By 2005, it had grown to ~26 gallons per person per year (1). By 2012, touching 30 gallons per person per year (see figure below from 2), it had become the veritable 'superstar of the beverage industry' (3).


The US sociologist, Andrew Szasz offers an intriguing explanation for the explosion in bottled water consumption in recent decades. Calling it the phenomenon of 'inverted quarantine', modeled after quarantine, he characterizes it as a distinct consumer response to widespread threats, both perceived and real. In classic quarantine, the collective community and environment are deemed healthy and some discrete sources within it present a spreadable danger. The community then protects itself by isolating that source, i.e., the diseased individual(s). This reduces the chance that others will get exposed and spread the infection. What happens when the threat is perceived to be everywhere? When the surrounding environment itself is perceived to be toxic, dangerous? According to Szasz, in the US, many healthy individuals responded by isolating themselves from their disease-inducing environment. Healthy and relatively affluent. Hence 'inverted quarantine', a walling-off response to threats perceived everywhere, gated communities perhaps the purest expression yet of such impulses.
Contrasting it with past social movements which brought about change through collective action, Szasz characterizes choices to buy bottled water, and 'organic', 'natural', 'non-toxic' food, household and personal hygiene products as ultimate expressions of individualism. 'Assembling a personal commodity bubble for one's body' (3), an attempt to shop one's way out of trouble instead of banding together collectively to change the status quo. In the case of bottled water, it started with a long-perceived suspicion of tap water. Long before the tragic Flint water crisis, US residents reported their tap water mistrust in survey after survey (3, Chapter 3, reference 5).
'The 1999 National Consumer Water Quality Survey found that “about three -quarters [of American adults] have some concern regarding the quality of their household water supply” and “almost half are concerned about possible health-related contaminants.” Two years later, a follow -up survey found those numbers had grown bigger still. Eight -six percent agreed they had “concerns about their water,” and “51 percent worried about possible health contaminants.'
In other words, widespread perception of toxic industrial and agricultural chemicals polluting tap water. Once the beverage industry understood this was driving consumer interest in bottled water, it set about explicitly marketing it as a safer alternative to assuage precisely these concerns. While bottled spring water brands pitched the pristine purity of their bottled water (see some examples below from 3, chapter 3)...

Odwalla
'ANCIENT FRESHNESS™—The Odwalla water you are now meeting fell on the land as rain, snow, and glacial melt 16,000 years ago. When it began its circular journey deep into the earth, ecosystems were in balance, the air was clear, the landscape wild and primeval. It carried this prehistoric purity underground, where it has remained totally isolated from environmental changes. —This water is as pure as the day it fell to Earth 16,000 years ago.78'
Fiji Water
'water that has never been touched by pollution or dirtied by pollution because it was created hundreds of years before the industrial revolution and it’s been locked under the earth in an aquifer in Fiji . . . at the very edge of a primitive rainforest, 1,500 miles away from the nearest continent. . . . Far from pollution. Far from acid rain. Far from industrial waste. . . . when it comes to drinking water, “remote” happens to be very, very good.79'
...Brands sourcing their water from the public water system focused on the 'hypertechnological efforts' (3) to render the hitherto toxic pure (see some examples below from 3, chapter 3).

Big Sur Water Company
'goes through a carbon filter . . . then [it is] put through a vapor compression™ processor . . . then through a 1 micron . . . paper filter . . . [finally,] As the water then goes toward the filler, superoxygen in the form of ozone (O3) is injected into the water to assure our water will remain in a pure state after it is bottled.81'
Ionic
'The process used to purify and produce Aqua CoolR Pure Bottled Water involves the use of The Ionics ToolboxSM of technologies [that ToolboxSM has in it: Electrodialysis Reversal, Reverse Osmosis, Ultrafiltration, Adsorption] to obtain the complete removal of all dissolved and undissolved materials from the source water. The resulting highly pure water is then remineralized with a specific “menu” of minerals selected for taste and fortification.82'
Once such relentless, focused marketing succeeded and how (see an eyebrow-raising example below from Wikipedia), a virtuous positively reinforcing cycle came into existence. And it's a hard one to knock off. After all, the perceived threat is the subtle one of long-term consequences of ingesting low doses of 'toxic' pollutants present in tap water. Once beverage company marketers succeeded in convincing consumers of the superior safety of their product, it required less effort in expanding its appeal by pitching it to the health-conscious as a lifestyle choice. And thus, bottled water sales increase year on year.


Irony of choosing bottled water over tap water is it implicitly imbues beverage companies with saintly trustworthiness that may be just as unwarranted.

Bibliography
1. Beverage Marketing Corporation of New York, “News Release: Bottled Water Continues Tradition of Strong Growth in 2005,” April 2006, Consulting, Advisory Services, Trend Data and Market Reports for the Global Beverage Industry
2. Bottled Water Sales: The Shocking Reality. Peter Gleick, April 25, 2013.

https://www.quora.com/Why-do-people-believe-that-bottled-water-is-better-than-tap-water/answer/Tirumalai-Kamala


Sunday, November 20, 2016

Are there any animals that actually enjoy being hugged by humans?


Question could be examined from at least three angles.
  • How do animals react to a human's hug as in are there any physiological similarities between animal and human response to hugs?
  • Do animals offer hugs to each other in their native habitats in social contexts plausibly similar to those among humans?
  • Do animals offer hugs to humans?
Currently there seem to be scientific studies about the first two but not the last question.

How do animals react to a human's hug? Examples from Indirect Dog Studies.
What's a hug but a gesture of affection, consolation and/or support? If pet dogs expected such affectionate gestures from their human parents/owners as a matter of course, a logical extension would be that such expectations entail possessiveness expressed as jealousy when the dogs see those same gestures extended to others in their environment. So do pet dogs express jealousy in such situations?

I. A 2012 Plos One study on 36 dogs studied in their homes suggested they became jealous when they observed a rival for their affection (1). The study videotaped the dogs' reactions when their human parents/owners ignored them to instead pay attention to a stuffed animal, a jack-o-lantern pail or a pop-up book they read aloud. The stuffed animal consisted of a realistic-looking dog that barked, wagged its tail and whined. The authors chose not to include real rival dogs because such situations would be more difficult to control and would have yielded results much more difficult to interpret. The dogs in the study included a variety of breeds ranging from a Boston terrier, Yorkshire terriers, chihuahuas, mutts and a pug.
The study found a clear hierarchy of perceived affection deprivation
  • 78% would push or touch the human parent/owner when they petted or sweet-talked the fake dog.
  • 42% became upset when the human parent/owner gave attention to the jack-o-lantern pail.
  • 22% became upset when the human parent/owner gave attention to the book.
Only a preliminary study so results can't be taken as conclusive and there are caveats as well. Study was small, only 36 dogs. The researchers didn't record the dogs' initial reactions to these new objects so we don't know if the dogs' reactions were to the objects per se or to human parents'/owners' interactions with them. However, the study does suggest that jealousy may not be solely a human construct nor based on sexual rivalry alone. Rather it may stem from 'the need to secure resources in all kinds of valued social relationships, be they sexual, parental, sibling, or just friendly' (2).

II. In a first of its kind study, animal cognition scientists at Eotvos Lorand University in Budapest trained dogs to lie still in an https://en.wikipedia.org/wiki/Ma... machine, and compared human (n=22) and canine (n=11) brain activity in response to different human and dog sounds such as voices, barks, and meaningful grunts and sighs that both species articulate (3). They found that happy sounds lit up the auditory cortex in both humans and dogs. According to Attila Andics, the neuroscientist and lead author of the study, dogs seems to be neurologically hardwired to pick up on their human companions' subtle mood shifts (4). This suggests they may welcome and appreciate hugs from their human parents/owners.

III. In another dog MRI study, Emory University also trained dogs (n=37) to lie still in an MRI machine and measured their neural responses to smells of familiar and unknown people using Functional magnetic resonance imaging (5). They found dog owners' smell triggered their brains' caudate nucleus, the brain's 'reward center'. This is extremely pertinent since dogs use their noses to navigate through the world. Study of how their brains process smell stimuli could improve our understanding of their social world, what's important, what's not, and how this process is similar or not to that in humans. In this case, smells of their human parents/owners seemed to be looped into their brains' reward circuits. Again, this suggests they'd likely enjoy being hugged by their human parents/owners. A follow-up fMRI study on 13 dogs found somewhat similar results in response to touch (6).

Caveats with these MRI studies is dogs were trained to sit motionless in the MRI machines using food rewards, i.e., essentially bribed to submit to such examinations (see photos below from 3). That definitely muddies the waters since it diminishes the dogs' autonomy in the experimental process (7).


Do animals offer hugs to each other in their native habitats? Example From A Chimpanzee Study.
If animals within a particular species are seen hugging each other, presumably they wouldn't mind hugs from humans either or at least from humans they're familiar with and perceive to be non-threatening. The former has indeed been documented in chimpanzees. In one of the largest studies of its kind and led by the acclaimed primatologist Frans de Waal, research showed two outdoor-housed groups of chimpanzees consistently and spontaneously consoled individuals with whom they were socially close, consolation defined as interaction 'in which an uninvolved bystander initiates friendly contact with a recent victim of aggression' (see photo below from 8).


Bibliography
1. Harris, Christine R., and Caroline Prouvost. "Jealousy in dogs." PloS one 9.7 (2014): e94597. http://journals.plos.org/plosone...
2. Dogs Get Jealous, Too. National Geographic, Jennifer S. Holland, July 23, 2014.
3. Andics, Attila, et al. "Voice-sensitive regions in the dog and human brain are revealed by comparative fMRI." Current Biology 24.5 (2014): 574-578. http://ac.els-cdn.com/S096098221...
4. Brain Scans Reveal What Dogs Really Think of Us. Science.Mic, Theresa Fisher, November 20, 2014.
5. Berns, Gregory S., Andrew M. Brooks, and Mark Spivak. "Scent of the familiar: An fMRI study of canine brain responses to familiar and unfamiliar human and dog odors." Behavioural processes 110 (2015): 37-46. Scent of the familiar: An fMRI study of canine brain responses to familiar and unfamiliar human and dog odors
6. Cook, Peter F., Mark Spivak, and Gregory S. Berns. "One pair of hands is not like another: caudate BOLD response in dogs depends on signal source and canine temperament." PeerJ 2 (2014): e596. https://peerj.com/articles/596.pdf
7. Dogs Are Not People. Boston Review, Colin Dayan, January 23, 2014.
8. Romero, Teresa, Miguel A. Castellanos, and Frans BM de Waal. "Consolation as possible expression of sympathetic concern among chimpanzees." Proceedings of the National Academy of Sciences 107.27 (2010): 12110-12115. http://www.pnas.org/content/107/...


https://www.quora.com/Are-there-any-animals-that-actually-enjoy-being-hugged-by-humans/answer/Tirumalai-Kamala


Sunday, November 13, 2016

How widely accepted is the link between meat consumption and climate change?



 Logic dictates that if the link between meat consumption and climate change were widely accepted, industrial meat production would decrease, governments would push policies towards achieving such a goal, and per capita meat consumption rates would decline. But simple, straightforward logic isn't the only attribute to guide our actions, is it? Instead, notwithstanding the link between global meat production and climate change, the data show that meat production and consumption are on the rise globally as industrialization globalizes, industrial agriculture replaces traditional small-scale farming and hundreds of millions of humans are pulled out of poverty. Why does affluence tend to go hand in hand with meat consumption? Meat eating's a status symbol for the newly affluent the world over. A look at some of the obscene, shocking numbers suffices to convince we're far from global peak industrial meat production and consumption (see figures below from 1, 2, 3, 4).

Industrial meat production's much more inefficient in energy conversion and much more unsustainable in terms of deforestation and desertification, i.e., much more costly for Mother Earth.
  • For e.g., massive forest cover's already been depleted in Brazil to make way for croplands needed to sustain food animal feed crops (soybean, corn).
  • Land taken over for monoculture crop production for animal feed tends to become degraded faster.
  • Industrial food animal production (IFAP) also requires massive freshwater use, this when increasing millions of humans the world over lack access to potable (safe drinking) water.
  • Animal poop and pee from IFAPs heavily pollute nearby lands and waterways, working their way through the ecosystem.
  • Also working their way through the ecosystem are the massive doses of antibiotics these hapless masses of animals are fed to accelerate their weight gain so they're ready for market that much sooner.
  • Not to mention the sheer immeasurable pain and suffering of billions of food animals housed in soul-destroying inhumane conditions.
Rounding off such a perfectly dreadful litany of intractable problems associated with IFAP is its unmistakable contribution to global greenhouse gas (GHG) emissions.

So why, in the face of all the most compelling data advising otherwise, are meat production and consumption increasing globally?
  • For one, IFAP's rise accompanies our increasing dissociation with the source of our food (2). It's not just food animal raising that's industrialized. So has their slaughter. The Brazilian company JBS is the world leader in animal slaughter. Its worldwide facilities can slaughter 85000 cattle, 70000 pigs and 12 million birds...every day. Following close on its heels is the US firm Tyson which can slaughter 170000 cattle, 350000 pigs and 42 million chickens...every week (2). And it isn't by accident that industrialized country IFAPs and abattoirs (slaughterhouses) are located far from cities in rural backwoods nor that they employ low-wage workers working in terrible conditions, i.e., captive labor market. Most industrial country consumers and increasingly, urban consumers in industrializing countries buy prettily packaged pre-cut slabs of meat in urban supermarkets, The Stepford Wives world far removed from the slaughterhouses with their rivers of blood, squeals, bulging eyes and sheer soul-chilling terror.
  • For another, why change current habits when there's no immediate penalty for the status quo and no incentive for change? After all, governments haven't shown much inclination to curb meat consumption nor taken a stance against IFAPs and CAFOs (Concentrated Animal Feeding Operation) nor have citizenry successfully prevailed upon them to do so.
  • Lastly, scientifically exploring the link between diet and climate change is of fairly recent vintage. It started in the late 1990s with Goodland saying 'diet matters' in the conversation about climate change (5). Since then many researchers have used life analysis and input-output models to estimate energy consumptions and GHG emissions of different foodstuffs (6, 7). Global meat production and climate change were first definitively linked in 2006 in a groundbreaking, massive (400 pages) study by Henning Steinfeld et al at the UN's Food and Agriculture Organization (FAO). This was the first study that clearly showed 'the livestock sector emerges as one of the top two or three most significant contributors to the most serious environmental problems' (8). They estimated global meat production contributes to 15 to 24% of total annual GHG emissions (5 to 7 X 109 tonnes per year).  Studies since show that meat and dairy production in particular are associated with disproportionately high GHG emissions (9, 10).
Since agriculture and related industrial activity are a massive part of the global economy, and directly and indirectly employ at least 1/7th of the global human population, there's been immediate and sustained pushback against the argument linking IFAP to GHG emission (see reference 8's wikipedia page for sources and their rationale). However, the conflict of interest inherent in the stance of such stakeholders renders their arguments weak and unconvincing.

Meantime, as the figures above show, meat production in places like China and Brazil has only increased even more steeply in the last few years. This means global meat production's contribution to GHG is only increasing, not decreasing and it will continue to do so unless and until governments intervene with specific policy changes. They could stop or curtail massive subsidies to agriculture for example so that we each pay the real price for our food. Pigs are likely to fly sooner. Yet if nothing changes, inevitable major environmental cataclysms from anthropogenic global warming (AGW) will likely hijack the agenda willy-nilly or IFAP-sourced pandemics will help wipe out a substantial chunk of global human population (11). Our pathetic history of collective problem solving shows these latter possibilities are far more likely than timely and wise government intervention, and when such eventualities inevitably come to pass, those humans unlucky enough to survive such apocalyptic catastrophes will perforce need to change their obscenely profligate abuse of Earth and domesticated animals. In fact, such survivors would likely no longer be able to dictate terms and the Earth will be all the more better off for it.

Bibliography
1. Growing greenhouse gas emissions due to meat production. UN Environment Programme (UNEP), 2012. http://www.unep.org/pdf/unep-gea...
2. Meat Atlas: Facts and Figures about the animals we eat. Heinrich Boll Stiftung, 2014. https://www.bund.net/fileadmin/b....
3. FAOSTAT
4. Thornton, Philip K. "Livestock production: recent trends, future prospects.” Philosophical Transactions of the Royal Society of London B: Biological Sciences 365.1554 (2010): 2853-2867. http://rstb.royalsocietypublishi...
5. Goodland, Robert. "Environmental sustainability in agriculture: diet matters." Ecological Economics 23.3 (1997): 189-200. http://www.is.cnpm.embrapa.br/bi...
6. Coley, David A., Emma Goodliffe, and Jennie Macdiarmid. "The embodied energy of food: the role of diet." Energy policy 26.6 (1998): 455-460.
7. Phetteplace, Hope W., Donald E. Johnson, and Andrew F. Seidl. "Greenhouse gas emissions from simulated beef and dairy livestock systems in the United States." Nutrient cycling in agroecosystems 60.1-3 (2001): 99-102. https://www.researchgate.net/pro...
8. Steinfeld, H., Gerber, P., Wassenaar, T., Castel, V., Rosales, M. and de Haan, C. (2006). Livestock’s long shadow: Environmental issues and options. Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. Livestock's Long Shadow
9. Eshel, Gidon, and Pamela A. Martin. "Diet, energy, and global warming." Earth interactions 10.9 (2006): 1-17. http://www.environmentalcalculat...
10. Stehfest, Elke, et al. "Climate benefits of changing diet." Climatic change 95.1-2 (2009): 83-102. http://dels.nationalacademies.or...
11. Leibler, Jessica H., et al. "Industrial food animal production and global health risks: exploring the ecosystems and economics of avian influenza." Ecohealth 6.1 (2009): 58-70. http://are.berkeley.edu/~dwrh/CE...


https://www.quora.com/How-widely-accepted-is-the-link-between-meat-consumption-and-climate-change/answer/Tirumalai-Kamala